Webb was the fourth man to take charge of Orient this season - their 10th manager in less than three years - but after just two wins in 12 games in charge the 33-year-old has left his post with immediate effect along with goalkeeper coach Martin Brennan
Assistant manager Omer Riza will take over duties as first-team manager until the end of the season
A statement on the club's website read: "The club can confirm they have accepted the resignation of Danny Webb from his post as first team manager
"Webb took over the job on January 29, picking up two wins from his 12 games in charge, but leaves the club with immediate effect along with goalkeeper coach Martin Brennan.
"Omer Riza will take over duties of first team manager until the end of the season, and his first game in charge will be Saturday's home Sky Bet League Two game against Wycombe Wanderers
He's very determined to make sure that the team finishes the season strong and he's looking forward for the challenge."
The news of his Webb's resignation comes just weeks after a winding-up petition against the club was adjourned until June to give the owner more time to pay off outstanding debts
The 33-year-old was initially meant to be hired as first-team manager last summer but was made Andy Edwards' assistant following a managerial change in November
Webb was given the role in January after Edwards took up a coaching role in the Football Association
Orient were on the brink of promotion to the Championship in the 2014 but suffered a penalty shoot-out defeat to Rotherham in the League One play-off final
The club's status in the Football League now look slim with seven games remaining
The O's are currently seven points adrift at the bottom of League Two
Source : PA